The incidence of BK virus infection in kidney transplant recipients has increased over recent decades, coincident with the use of\r\nmore potent immunosuppression. More importantly, posttransplant BK virus replication has emerged as an important cause of\r\ngraft damage and subsequent graft loss. Immunosuppression has been accepted as a major risk for BK virus replication. However,\r\nthe specific contribution of individual immunosuppressive medications to this risk has not been well established. The purpose of\r\nthis paper is to provide an overview of the recent literature on the influence of the various immunosuppressant drugs and drug\r\ncombinations on posttransplant BK virus replication. Evidence supporting the various immunosuppression reduction strategies\r\nutilised in the management of BK virus will also be briefly discussed.
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